Values of blood copeptin level as a marker of unfavorable forecast in subarachnoid haemorrhage of the brain of atraumatic origin
Objective – to evaluate of diagnostic informativeness of сopeptin serum values in determining the risk of complications in patients with subarachnoid hemorrhage.
Materials and methods. A prospective cohort study of 82 patients (40 men and 42 women) with spontaneous (non-traumatic) subarachnoid hemorrhage (SAH) from the age of 23 to 72 years (average age – (49,6 ±1,3) year) was conducted.
Results. Complications were recorded in 31 (74.20 %) patients with a serum level of copeptin ≥ 0.605 ng/ml on the third day of the SAH, which was in 9.49 times higher (95 % CI 3.60–24.80, р ˂0.0001) than in patients with a serum level of copeptin < 0.605 ng/ml. When determining the cumulative risk of developing complications of SAH, the values of positive and negative predictive values of serum levels of copeptin on third day of SAH were 74.19 % and 92.20 % respectively, the accuracy of prediction (the sum of correctly classified observations) was 85.39 %.
Conclusions. ROC-analysis suggests that the serum level of copeptin on third day of SAH ≥ 0.605 ng/ml is characterized by an optimal ratio of sensitivity and specificity in assessing the cumulative risk of developing such SAH complications as secondary ischemia combined with cerebral angiospasm.
Pedachenko JuE, Guk AP, Nikiforova AN. Nejrohirurgicheskaja pomoshh pri cerebrovaskuljarnyh boleznjah v Ukraine. Analiz statisticheskih dannyh nejrohirurgicheskoj sluzhby. Ukrainskij nejrohirurgicheskij zhurnal. 2017;1:33-39. (in Russian)
Ahn SH, Savarraj JP, Pervez M et al. The subarachnoid hemorrhage early brain edema score predicts delayed cerebral ischemia and clinical outcomes. Neurosurgery. 2018;83(1):137-45. doi: 10.1093/neuros/nyx364.
de Oliveira Manoel AL, Goffi A et al. The critical care management of poor-grade subarachnoid haemorrhage. Crit Care. 2016;20:21. doi: 10.1186/s13054-016-1193-9.
Gaasch M, Schiefecker AJ, Kofler M et al. Cerebral autoregulation in the prediction of delayed cerebral ischemia and clinical outcome in poor-grade aneurysmal subarachnoid hemorrhage patients. Crit Care Med. 2018;46(5):774-80. doi: 10.1097/CCM.0000000000003016.
Rass V, Helbok R. Early brain injury after poor-grade subarachnoid hemorrhage. Curr Neurol Neurosci Rep. 2019 Aug 29;19(10):78. doi: 10.1007/s11910-019-0990-3.
Weimer JM, Jones SE, Frontera JA. Acute cytoto-xic and vasogenic edema after subarachnoid hemorrhage: a quantitative MRI study. Am J Neuroradiol. 2017;38(5):928-34. doi: 10.3174/ajnr.A5181.
Yang DB, Yu WH, Dong XQ. Plasma copeptin level predicts acute traumatic coagulopathy and progressive hemorrhagic injury after traumatic brain injury. Peptides. 2014 Aug;58:26-9. doi: 10.1016/j.peptides.2014.05.015.
Wei ZJ, Ou YQ, Li X, Li H. The 90-day prognostic value of copeptin in acute intracerebral hemorrhage. Neurol Sci. 2014 Nov;35(11):1673-9. doi: 10.1007/s10072-014-1809-2.
Yu WH, Wang WH, Dong XQ. Prognostic significance of plasma copeptin detection compared with multiple biomarkers in intracerebral hemorrhage. Clin Chim Acta. 2014 Jun 10;433:174-8. doi: 10.1016/j.cca.2014.03.014.
De Marchis GM, Katan M, Weck A, Brekenfeld C. Copeptin and risk stratification in patients with ischemic stroke and transient ischemic attack: the CoRisk study. Int J Stroke. 2013 Apr;8(3):214-8. doi: 10.1111/j.1747-4949.2011.00762.x.
This work is licensed under a Creative Commons Attribution 4.0 International License.