Virus persistence in atherosclerotic plaques in patients after carotid endarterectomy
Abstract
Objective ‒ to mark the quantity of herpes and flu infection detection of the none-stabil and stabil atherosclerotic (AS) plaques in patients with ischemic stroke (IS)/TIA and with the progressing AS and in the anamnesis after carotid endarterectomy.
Materials and methods. 103 patients with IS/TIA after carotid endarterectomy were examined: 67 males 42‒82 years old (average age ‒ 66,1±1,4 years), 36 females 44‒81 years old (average age ‒ 63,0±1,3 years). Average age ‒ 65,1± 0,9 year. We examined the width of intima-media complex, presence of AS plaques, their constitution.
Results. Among all viruses investigated with transfection and polymerase chain reaction in AS plaques and blood after carotid endarterectomy (HSV1,2, ЕВV, CMV, HHV6), the most prefer are with CMV and associated CMV + HSV1, CMV + HSV2, where patients, hwo have HHV6 and associated HSV1 + HHV6, HHV6 + HSV1 + HSV2.
Conclusions. Presentation of CMV and associated CMV + HSV1, CMV + HSV2 increases the risk of development of the hypoechoic none-stabil AS plaques of internal carotid artery (ICA). Presentation of HHV6 and associated HSV1 + HHV6, HSV1 + HSV2 + HHV6 in AS plaques of ICA increases the relative risk of development of severe stenosis in the patients with symptomatic stenosis. The investigation confirms the necessary of periodical administration at exclusion of the stenosis of ICA.
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References
Bayer-Karpinska A, Schindler A, Saam T. Detection of vulnerable plaque in patients with cryptogenic stroke. Neuroimaging Clin N Am. 2016;26(1):97-110. https://doi.org/10.1016/j.nic.2015.09.008.
Simon DI. Inflammation and vascular injury: basic discovery to drug development. Circ J. 2012;76(8):1811-8. https://doi.org/10.1253/circj.cj-12-0801.
Mihaylenko AA. Klinicheskiy praktikum po nevrologii. SPb.: Foliant; 2001 (In Russian)
Kupryushin AS, Chudaeva DG, Fedorova MG i dr. Modern issue on the role of microorganisms in the induction and the development of atherosclerosis (review). Saratov Scientific Medical Journal. 2016;12(2):113-7. (In Russian)
Virmani R, Burke AP, Farb A, Kolodgie FD. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006 Apr 18;47(8 Suppl):C13-8. https://doi.org/10.1016/j.jacc.2005.10.065.
Mas S, Touboul D, Brunelle A et al. Lipid cartography of atherosclerotic plaque by cluster-TOF-SIMS imaging. Analyst. 2007;132(1):24-6. https://doi.org/10.1039/b614619h.
Alonso A, Artemis D, Hennerici MG. Molecular imaging of carotid plaque vulnerability. Cerebrovasc Dis. 2015;39(1):5-12. https://doi.org/10.1159/000369123.
McNally JS, McLaughlin MS, Hinckley PJ et al. Intraluminal thrombus, intraplaque hemorrhage, plaque thickness, and current smoking optimally predict carotid stroke. Stroke. 2015;46(1):84-90. https://doi.org/10.1161/STROKEAHA.114.006286.
Ragino YI, Volkov AM, Chernyavsky AM. Stages of atherosclerotic plaque development and unstable plaque types: pathophysiologic and histologic characteristics. Ros. cardiol. zhurn. [Russ J Cardiol]. 2013;5:88-95. (In Russian)
Brinjikji W, Huston J, Rabinstein AA et al. Contemporary carotid imaging: from degree of stenosis to plaque vulnerability. J Neurosurg. 2016;124(1):27-42. https://doi.org/10.3171/2015.1.JNS142452.
Dubenko OE, Zubkov AV, Anisenkova VYu, Kra-syuk DO. The carotid stenosius progression evaluation in patients with ischemic stroke who underwent carotid endarterectomy. Ukr. Neurol. Zhurn. 2019;(2-3):29-34. https://doi.org/10.30978/UNJ2019-2-29. (In Russian)
Okazaki S, Sakaguchi M, Miwa K et al. Association of interleukin-6 with the progression of carotid atherosclerosis: a 9-year follow-up study. Stroke. 2014 Oct;45(10):2924-9. https://doi.org/10.1161/STROKEAHA.114.005991.
De Weerd M, Greving JP, Hedblad B et al. Prevalence of asymptomatic carotid artery stenosis in the ge-neral population: an individual participant data meta-analysis. Stroke. 2010;41(6):1294-7. https://doi.org/10.1161/STROKEAHA.110.581058
Klinicheskaya angiologiya: rukovodstvo: v 2 t. Pod red. AV Pokrovskogo. M.: Meditsina, 2004. Vol.1. (In Russian)
Lal BK, Beach KW, Roubin GS et al. Restenosis after carotid artery stenting and endarterectomy: a se-condary analysis of CREST, a randomised controlled trial. Lancet Neurol. 2012;11(9):755-63. https://doi.org/10.1016/S1474-4422(12)70159-X.
Rautou PE, Vion AC, Amabile N et al. Microparticles, vascular function, and atherothrombosis. Circ Res. 2011;109(5):593-606. https://doi.org/10.1161/CIRCRESAHA.110.233163.
Shlichkova TP, Zhdanov VS, Karpov YuA. The main types of unstable atherosclerotic plaques and their prevalence in the coronary arteries in acute myocardial infarction. Arch Pathology. 2005;3:24-8. (In Russian)
European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis. 2008;25(5):457-507. https://doi.org/10.1159/000131083.
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