Spontaneous occlusion of the cerebral arteriovenous malformations

  • D.V. Shchehlov SO «Scientific-practical Center of endovascular neuroradiology NAMS of Ukraine», Kyiv, Ukraine
  • O.E. Svyrydiuk SO «Scientific-practical Center of endovascular neuroradiology NAMS of Ukraine», Kyiv, Ukraine
  • S.V. Chebanyuk SO «Scientific-practical Center of endovascular neuroradiology NAMS of Ukraine», Kyiv, Ukraine
  • O.V. Slobodian SO «Scientific-practical Center of endovascular neuroradiology NAMS of Ukraine», Kyiv, Ukraine
  • M.B. Vyval SO «Scientific-practical Center of endovascular neuroradiology NAMS of Ukraine», Kyiv, Ukraine https://orcid.org/0000-0002-9428-4678
Keywords: cerebral arteriovenous malformation; spontaneous occlusion; angiography; observation; natural course.


Spontaneous occlusion of arteriovenous malformations (AVM), characterized by complete disappearance of the AVM nidus and early venous drainage, and is a rare. The frequency of this phenomenon varied from 0.1 to 1.3 %.
We analyzed two cases of spontaneous occlusion of cerebral AVMs with a non-hemorrhagic debut after 3 and 13 years in women aged 28 and 40 years, respectively. In both cases AVM was diagnosed during routine neuroimaging because of headache. Both patients had superficial small malformations. After discussing the risks of surgical treatment, both patients refused to perform any intervention. Scheduled angiography was performed 3 years after the diagnosis to follow-up the course of the disease and revealed complete disappearance of the AVM. Another patient noted persistent regression of headache after 3 years. Follow-up angiography was performed 13 years after diagnosis and confirmed spontaneous occlusion of the AVM. Given the data on the recurrence of the disease after spontaneous occlusion, such patients require long-term follow-up.
When an AVM ruptures, hemodynamic changes may explain the thrombosis of the malformation, but the mechanisms of spontaneous occlusion in non-ruptured AVM remain unclear.


Download data is not yet available.


Derdeyn CP, Zipfel GJ, Albuquerque FC, et al. Management of brain arteriovenous malformations. a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2017;48(8):e200-e224. DOI: 10.1161/STR.0000000000000134 PMID: 28642352

Gross BA, Du R. Natural history of cerebral arteriovenous malformations: a meta-analysis. J Neurosurg. 2013;118(2):437-43. DOI: 10.3171/2012.10.JNS121280 PMID: 23198804

Karnoub MA, Aboukais R, Obled L, et al. Spontaneous disappearance of brain arteriovenous malformation: A case series. Neurochirurgie. 2022 Feb;68(2):163-7. doi: 10.1016/j.neuchi.2021.08.002. Epub 2021 Aug 21. PMID: 34428471.

Buis DR, van den Berg R, Lycklama G, van der Worp HB, Dirven CM, Vandertop WP. Spontaneous regression of brain arteriovenous malformations. A clinical study and a systematic review of the literature. J Neurol. 2004;251(11):1375-82. DOI: 10.1007/s00415-004-0548-3 PMID: 15592734

Hamada J, Yonekawa Y. Spontaneous disappearance of a cerebral arteriovenous malformation: case report. Neurosurgery. 1994;34(1):171-3. PMID: 8121555

Abdulrauf SI, Malik GM, Awad IA. Spontaneous angiographic obliteration of cerebral arteriovenous malformations. Neurosurgery. 1999;44(2):280-7. DOI: 10.1097/00006123-199902000-00021 PMID: 9932881

Matano F, Murai Y, Nakagawa S, Wada T, Kitamura T, Teramoto A. Spontaneous angiographic regression of cerebral arteriovenous malformations: angiographic disappearance is not the real cure. Turk Neurosurg. 2015;25(1):168-73. DOI: 10.5137/1019-5149.JTN.9579-13.4 PMID: 25640565

Conforti P. Spontaneous disappearance of cerebral arteriovenous angioma. Case report. J Neurosurg. 1971;34(3):432-4. DOI: 10.3171/jns.1971.34.3.0432 PMID: 5547322

Minakawa T, Tanaka R, Koike T, Takeuchi S, Sasaki O. Angiographic follow-up study of cerebral arteriovenous malformations with reference to their enlargement and regression. Neurosurgery. 1989;24(1):68-74. DOI: 10.1227/00006123-198901000-00011 PMID: 2927601

Lee SK, Vilela P, Willinsky R, TerBrugge KG. Spontaneous regression of cerebral arteriovenous malformations: clinical and angiographic analysis with review of the literature. Neuroradiology. 2002;44(1):11-6. DOI: 10.1007/s002340100702 PMID: 11942493

Lidegaard Ø, Edstrom B, Kreiner S. Oral contraceptives and venous thromboembolism: a five-year national case-control study. Contraception. 2002;65(3):187-96. DOI: 10.1016/s0010-7824(01)00307-9 PMID: 11929640

Lidegaard Ø, Kreiner S. Cerebral thrombosis and oral contraceptives. A case-control study. Contraception. 1998;57(5):303-14. DOI: 10.1016/s0010-7824(98)00032-8 PMID: 9673837

Mabe H, Furuse M. Spontaneous disappearance of a cerebral arteriovenous malformation in infancy. Case report. J Neurosurg. 1977;46(6):811-5. DOI: 10.3171/jns.1977.46.6.0811 PMID: 859017

Mizutani T, Tawaka H, Aruga T. Total recanalization of a spontaneously thrombosed arteriovenous malformation: a case report. J Neurosurg. 1995;82:506-8. DOI: 10.3171/jns.1995.82.3.0506 PMID: 7861234

Nukui H, Miyagi O, Tamada J, Mitsuka S, Kawafushi J. Long-term follow-up study by cerebral angiography in cases with arteriovenous malformation of the brain, with special reference to spontaneous disappearance of arteriovenous malformation in cerebral angiography (author’s transl). Neurol Med Chir (Tokyo). 1982;22(2):125-32. (in Japanese) DOI: 10.2176/nmc.22.125 PMID: 6178048

How to Cite
Shchehlov, D., Svyrydiuk, O., Chebanyuk, S., Slobodian, O., & Vyval, M. (2022). Spontaneous occlusion of the cerebral arteriovenous malformations. Ukrainian Interventional Neuroradiology and Surgery, 39(1), 34-39. https://doi.org/10.26683/2786-4855-2022-1(39)-34-39

Most read articles by the same author(s)