Use of stents with medication coating for the treatment of occlusive-stenotic lesions of the superficial femoral artery

  • O.L. Nikishyn SО «Scientific-Practical Center of Endovascular Neuroradiology NAMS of Ukraine», Kyiv, Ukraine
  • I.V. Altman SО «Scientific-Practical Center of Endovascular Neuroradiology NAMS of Ukraine», Kyiv, Ukraine
  • I.I. Al-Qashgish SО «Scientific-Practical Center of Endovascular Neuroradiology NAMS of Ukraine», Kyiv, Ukraine
  • A.I. Gavretskiy Ukrainian Military Medical Academy, Kyiv, Ukraine
  • S.I. Savoluk Shupyk National Health University, Kyiv, Ukraine
  • M.I. Muz Kyiv City Clinical Hospital N 8, Ukraine
Keywords: critical lower limb ischemia; diabetic angiopathy; diabetic foot syndrome; stenting; restenosis; angioplasty; shunting.


Objective ‒ to analyze the results of endovascular revascularization of the femoropopliteal segment with drug-eluting stents.
Materials and methods. Endovascular intervention was performed in 23 patients with stenotic lesions of the superficial femoral artery (SFA). Paclitaxel-eluting stents were used. There were 10 men (43.5 %), 13 women (56.5 %). The mean age of the patients was (66.0 ± 3.5) years. There were 16 (69.6 %) patients with diabetes mellitus type 2 and diabetic angiopathy, and 7 (23.4 %) patients had obliterating atherosclerosis of the arteries of the lower limbs. Critical ischemia of the lower extremities was diagnosed in 18 (56.5 %) cases, intermittent claudication ‒ in 5 (21.7 %). Isolated lesions of the femoral-popliteal segment were noted in 3 (13.4 %) patients, lesions of the iliac and femoral-popliteal segments ‒ in 4 (17.4 %), lesions of the femoral-popliteal and ankle segments ‒ in 16 (69.6 %).
Results. Twenty (86.6 %) scheduled procedures for stenting of the SFA were technically successful. Among postoperative complications, 3 (13.04 %) patients had puncture site hematomas that did not require surgical evacuation. In 6 (26.1 %) patients, signs of reperfusion syndrome were observed, which were treated with conservative treatment. During follow-up period (3 months), there were no cases of reocclusion or clinically significant restenosis at the stented level. In 1 (5.0 %) case, a hemodynamically significant stenosis of the SFA was observed outside the implanted stent. The patient successfully underwent angioplasty of SFA stenosis. There were no «major» amputations during follow-up period. «Small» ankle amputations were performed in 7 (35.0 %) patients with diabetic gangrene, where endovascular revascularization of the femoro-popliteal and ankle segments was the stage of surgical treatment.
Conclusions. Implantation of drug-eluting stents is an effective method of endovascular revascularization in patients with SFA lesions. To compare the results of implantation of drug-eluting stents with other methods of revascularization of the lesions of the femoro-popliteal segment, it is necessary to accumulate more data and increase the duration of the follow-up period.


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Nikishyn OL, Muz MI, Havretskyi AI, Altman IV, Savoliuk SI. Aktualni pytannia vykorystannia stentuvannia u likuvanni krytychnoi ishemii nyzhnikh kintsivok Endovaskuliarna neirorenthenokhirurhiia. 2017;(4):23-7. doi: 10.26683/2304-9359-2017-4(22)-23-27 (In Ukrainian)

Antonopoulos CN, Mylonas SN, Moulakakis KG, et al. A network meta-analysis of randomized controlled trials comparing treatment modalities for de novo superficial femoral artery occlusive lesions. J Vasc Surg. 2017 Jan;65(1):234-45.e11. doi: 10.1016/j.jvs.2016.08.095. PMID: 27865639.

Kayssi A, Al-Atassi T, Oreopoulos G, Roche-Nagle G, Tan KT, Rajan DK. Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for peripheral arterial disease of the lower limbs. Cochrane Database Syst Rev. 2016 Aug 4;2016(8):CD011319. doi: 10.1002/14651858.CD011319.pub2. PMID: 27490003; PMCID: PMC8504434.

Jongsma H, Bekken JA, de Vries JP, Verhagen HJ, Fioole B. Drug-eluting balloon angioplasty versus uncoated balloon angioplasty in patients with femoropopliteal arterial occlusive disease. J Vasc Surg. 2016 Nov;64(5):1503-14. doi: 10.1016/j.jvs.2016.05.084. PMID: 27478005.

Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group. Global vascular guidelines on the management of chronic limb-threa-tening ischemia. J Vasc Surg. 2019 Jun;69(6S):3S-125S.e40. doi: 10.1016/j.jvs.2019.02.016. Epub 2019 May 28. Erratum in: J Vasc Surg. 2019 Aug;70(2):662. PMID: 31159978; PMCID: PMC8365864.,

Koifman E, Lipinski MJ, Buchanan K, et al. Comparison of treatment strategies for femoro-popliteal disease: A network meta-analysis. Catheter Cardiovasc Interv. 2018 Jun;91(7):1320-8. doi: 10.1002/ccd.27484. Epub 2018 Jan 14. PMID: 29332315.

Tepe G, Laird J, Schneider P, Brodmann M, Krishnan P, Micari A, Metzger C, Scheinert D, Zeller T, Cohen DJ, Snead DB, Alexander B, Landini M, Jaff MR; IN.PACT SFA Trial Investigators. Drug-coated balloon versus standard percutaneous transluminal angioplasty for the treatment of superficial femoral and popliteal peripheral artery disease: 12-month results from the IN.PACT SFA randomized trial. Circulation. 2015 Feb 3;131(5):495-502. doi: 10.1161/CIRCULATIONAHA.114.011004. PMID: 25472980; PMCID: PMC4323569.

Bosiers M, Setacci C, De Donato G, et al. ZILVERPASS study: ZILVER PTX stent vs bypass surgery in femoropopliteal lesions. J Endovasc Ther. 2020 Apr;27(2):287-95. doi: 10.1177/1526602820902014. Epub 2020 Jan 30. Erratum in: J Endovasc Ther. 2020 Feb 18;1526602820908729. PMID: 31997715.

How to Cite
Nikishyn, O., Altman, I., Al-Qashgish, I., Gavretskiy, A., Savoluk, S., & Muz, M. (2023). Use of stents with medication coating for the treatment of occlusive-stenotic lesions of the superficial femoral artery. Ukrainian Interventional Neuroradiology and Surgery, 41(3), 38-45.